Paxil and cancer
Question:
What’s this latest scare about? Too small a study to worry about? Anybody rethinking their med?
Response:
>What’s this latest scare about? Too small a study to worry about? >Anybody rethinking their med?
Nick, This isn’t meant to imply that some study (I’m not aware of a study, I’m just giving you a "what if" answer) showing a link to cancer from taking Paxil is baloney, but it does help to keep things in perspective too. In the U.S. and probably most other countries, testing is exhaustive before a drug gets a green light to be marketed. However, you can still have freak instances where someone might have a predisposition to getting cancer when a certain food certain food or drug is repeatedly ingested and sets the wheels in motion. Unless the link is pretty transparent though, such as with cigarettes, I remind myself of what hot dog producers said after a definite link was proven for nitrites causing cancer in test mice. (Hot dogs and other cured meats use nitrites in the manufacturing process as a preservative so it’s a pretty essential ingredient.) A paraphrase of what was said is that the quantity of nitrites administered to the mice was equivalent to a human eating 10,000 hot dogs a day. What people in the U.S. sometimes forget is that the Delaney Act requires carcinogenic testing with no limit as to the amount of chemical(s) administered in test animals. Therefore by administering massive doses of nitrites to the mice, the link between nitrites and cancer and therefore hotdogs was found to have validity. Doug
Response:
Anyone heard of doctor anne blake tracey? not sure if i’m spelling that right but her opinion is she’s totally against SSRI type drugs she was on the artbell show(YES the nutso show) and I also heard on another radio program.
– Hide quoted text — Show quoted text -> What’s this latest scare about? Too small a study to worry about? > Anybody rethinking their med?
Response:
I heard her on the Art Bell Show (by the way it is not a nutso show) she did not convince me, she seemed as though she really did not know what she was talking about, she hemmed and hawed through every question asked of her and basically was just on there to promote her book. She did ramble off a few interesting facts now and again but the overall feeling I got from her is that she did not possess the knowledge to support her claims. Please let me know your thoughts on her presentation on the Art Bell Show.
– Hide quoted text — Show quoted text -> Anyone heard of doctor anne blake tracey? not sure if i’m spelling that > right but her opinion is she’s totally against SSRI type drugs she was on > the artbell show(YES the nutso show) and I also heard on another radio > program. > What’s this latest scare about? Too small a study to worry about? > Anybody rethinking their med?
Response:
>I heard her on the Art Bell Show (by the way it is not a nutso show) she did >not convince me, she seemed as though she really did not know what she was >talking about, she hemmed and hawed through every question asked of her and >basically was just on there to promote her book. She did ramble off a few >interesting facts now and again but the overall feeling I got from her is >that she did not possess the knowledge to support her claims. Please let me >know your thoughts on her presentation on the Art Bell Show.
Despite the title, she isn’t a medical doctor, but has a PhD is something. Not sure what, but suspect origami. Whatever its for, it apparently allows her to practice as a psychologist though, AFAIK, she doesn’t have a psychology degree. Her basic premise is that SSRIs cause over secretion of serotonin in much the same way as methamphetamines. She is wrong, as any psycho pharmacologist will tell her. Indeed, many people have, but she continues to parrot the same wild claims. Draw your own conclusions! Bottom line – she just another doom sayer who doesn’t let the facts get in the way of selling books. Just don’t ask them for solutions to your problem. They, IME, rarely have any answers. Just gloom and doom. I’ve appended just a few of the studies showing that SSRIs (and other antidepressants) don’t increase serotonin (5-HT) expression, but actually reduce its synthesis/expression. Ian Stenfors C, Yu H, Ross SB. (2001) "Pharmacological characterisation of the decrease in 5-HT synthesis in the mouse brain evoked by the selective serotonin re-uptake inhibitor citalopram." Naunyn Schmiedebergs Arch Pharmacol, vol 363(2):p 222-32 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&… Cremers TI, Spoelstra EN, de Boer P, et al. (2000) "Desensitisation of 5-HT autoreceptors upon pharmacokinetically monitored chronic treatment with citalopram." Eur J Pharmacol, vol 397(2-3):p 351-7 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&… Alvarez JC, Sanceaume M, Advenier C, et al. (1999) "Differential changes in brain and platelet 5-HT concentrations after steady-state achievement and repeated administration of antidepressant drugs in mice." Eur Neuropsychopharmacol, vol 10(1):p 31-6 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&… Gur E, Dremencov E, Lerer B, Newman ME. (1999) "Venlafaxine: acute and chronic effects on 5-hydroxytryptamine levels in rat brain in vivo." Eur J Pharmacol, vol 372(1):p 17-24 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&… Zangen A, Overstreet DH, Yadid G. (1997) "High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment." J Neurochem, vol 69(6):p 2477-83 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&… Fekkes D, Timmerman L, Pepplinkhuizen L. (1997) "Effects of clomipramine on plasma amino acids and serotonergic parameters in panic disorder and depression." Eur Neuropsychopharmacol, vol 7(3):p 235-9 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&… Trouvin JH, Gardier AM, Chanut E, et al. (1993) "Time course of brain serotonin metabolism after cessation of long-term fluoxetine treatment in the rat." Life Sci, vol 52(18):p PL187-92 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&… Leonard BE. (1988) "Pharmacological effects of serotonin reuptake inhibitors." J Clin Psychiatry, vol 49 Suppl:p 12-7 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&… – Hide quoted text — Show quoted text -> Anyone heard of doctor anne blake tracey? not sure if i’m spelling that > right but her opinion is she’s totally against SSRI type drugs she was on > the artbell show(YES the nutso show) and I also heard on another radio > program.
Response:
Might as well stop eating bread, french fries, and potato chips too!
Response:
> Might as well stop eating bread, french fries, and potato chips too!
lol 
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